New Endorsing Organizations Added!
Recently, multiple studies have been published examining the response to SARS-CoV-2 mRNA-based vaccines in solid organ transplant (SOT) recipients.(1-7) Overall, these have demonstrated reduced antibody responses to vaccine when compared with reports involving the general public.
The low antibody response rate is concerning but not unexpected as SOT recipients have lower rates of immune responses to other vaccines as well.(8) Further data are needed to evaluate B- and T- cellular responses in SOT recipients after SARS-CoV-2 vaccination and to assess vaccine effectiveness particularly for protection against severe COVID-19 as a clinical end-point. Previous experience with influenza vaccination in transplant patients has demonstrated reduced influenza-related lower respiratory tract disease and hospitalization despite low antibody response.(9, 10). While breakthrough cases of COVID-19 after partial or full vaccination in SOT recipients may occur, it is important to recognize that we may be preventing more cases or reducing severity through vaccination.(11, 12) Thus, we strongly caution against concluding that low antibody response rate to SARS-CoV-2 vaccination will lead to reduced clinical effectiveness until more information is available. These results should not prompt or encourage vaccine hesitancy in SOT recipients.
Immunosuppressed patients are known to have prolonged viral shedding of actively replicating virus which may promote the development of viral variants.(13) Additionally, there are data to suggest worse outcomes in SOT recipients with COVID-19 compared to the general population.(14) The effect of immunization on duration of viral shedding and clinical outcomes remains unknown for this population.
Until more complete data are available, we urge:
Agnès Azimzadeh passed away on March 15, 2021, after a courageous battle with intestinal cancer. The scientific and clinical transplant communities she touched at Massachusetts General Hospital, University of Maryland, and around the world join her family in celebrating her life, and mourning her premature loss.
On Saturday, May 29th at 10:00AM EDT, her professional colleagues and former trainees will gather virtually to celebrate Agnes's life and her scientific contributions. A link to the gathering can be found at:
IXA-CTRMS are pleased to announce the extension of the abstract submission deadline until June 1, 2021.
We thank all authors from across the world who have already completed their submission. Please note that there will be no further extension to the deadline.
For guidelines and to submit your abstract click here
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