Transplantation - March 2022 Issue

JUST RELEASED - TRANSPLANTATION - MARCH ISSUE

The March issue heralds many new horizons and asks many new questions for the year ahead. An important national study from the UK provides us bad news on the poor efficacy of vaccines in transplant patients. Elsewhere excellent reviews on diabetes management after liver transplantation, robotic surgery, T cell exhaustion and innate immunity are accompanied by some well written and thought provoking articles on many aspects of liver, kidney, lung and heart transplantation. Guidelines on ERAS will be of use to many programs and a number of papers examine aspects of pediatric transplantation.

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Spotlighted News

How pig organs made their way into humans: The slow advance to transplant kidneys and hearts

Patrick Boyle, Senior Staff Writer, Association of American Medical Colleges
Feb. 23 - After 20-plus years of quiet research, doctors recently made history with four xenotransplants. Here is how they progressed and what they hope to achieve next.

Saving Lives One Kidney at a Time: Nearly 60 Years In, Dr. Robert Metzger Reflects on the Evolution of the AdventHealth Transplant Program

Feb. 9 - Nearly 60 years ago, Robert Metzger, MD, considered the Father of the AdventHealth Transplant Program, was a co-founder, developing the program at Florida Hospital. Through those years, critical advancements were made, and memorable surgeries have marked milestones in the program. Now, as Dr. Metzger begins retirement, he reflects, in his own words, on what was, and what he sees on the horizon for the next 10-15 years.

TTS 2022 - Argentina - September 10-14

Submit your abstract at the leading global congress in transplantation - Submission Deadline March 15

Did You Know?

  • Our abstract submission is free and registration payment is not required at the time of submission
  • TTS 2022 welcomes the submission of abstracts previously presented at national, regional or international meetings in the two years preceding the congress, as long as a manuscript has not been published
  • Accepted abstracts by a presenter registered to attend the Congress will be published in an online supplement of the Transplantation Journal
  • Abstracts are accepted under 22 topics for Oral, Mini-Oral, Campfire and Poster presentations
  • By submitting a high-quality abstract, young investigators, AHPs and members from emerging economies can apply for a Congress Scientific Award which includes a monetary grant to help offset expenses incurred to attend the Congress
TheThe submission deadline of March 15is fast approaching! Act fast and review the submission guidelines.

Help us spread the word! We have prepared a promotional toolkit which you can use to share the call for abstracts information on your social media, in your workplace and across your professional network.


2022 Mentee-Mentor Awards

The International Transplantation Science Mentee-Mentor Awards are designed to encourage dialogue and interactions between trainees and established investigators, and provide financial support for their joint participation in the Congress.

Transplantation
Week's Most Downloaded Paper

Transplantation Direct
Week's Most Downloaded Paper


Call for Social Media Ambassadors

TTS International Social Media Ambassadors

Share your TTS experience with thousands of international healthcare professionals and scientists by applying to be a Social Media Ambassador (SMA) for TTS!
What do TTS International Social Media Ambassadors do?
  • Work closely with our leadership and the TTS IHQ team to produce digital content (tweets, posts, blogs, vlogs, podcasts, interviews, calls to action, opinions, manuscript / article reviews and commentaries, etc.) to be posted on your own and TTS media channels. The over-arching theme is to drive engagement.
  • Promote TTS and its mission through social media channels.
  • Promote the TTS Congress and events through social media.
Requirements / Qualifications
We are looking for dynamic and passionate transplant professionals to be SMAs for the TTS. We plan to recruit numerous individuals for a period of one year, with a possibility of renewal thereafter. Each applicant would need to allocate 1-2 hours per week to advance this initiative and participate in TTS 2022 congress. Each applicant should have an active social media presence and excellent working knowledge of at least one social media platform; dedicated training/course preferable. We ask all interested applicants to provide a short description of why you would make a great social media ambassador and present a strategy to promote TTS and the upcoming congress in 500 words or less. Please mention a list of platforms currently used with social media handles and number of followers. TTS primarily posts in English however we are looking to expand our reach to better reflect the diversity within our membership.
Benefits of becoming a TTS-SMA
  • Recognition on the TTS website with photo, bio and links to social media accounts
  • Free registration at TTS 2022 Congress in Buenos Aires.
  • Opportunity for interaction with our leadership and the key-opinion leaders in transplantation
  • Opportunity to grow your own audience and career advancement
We may request a follow-up in-person meeting prior to our final selection.

TTS Call for Award Nominations - Deadline May 1

2022 Awards Call for Nominations

Medawar Prize

Call for nominations

Recognized as the world's highest dedicated award for the most outstanding contributions in the field of transplantation.

The Medawar Prize

The Medawar Prize, named after Society co-founder Sir Peter Medawar, is recognized as the world's highest dedicated award for the most outstanding contributions in the field of transplantation. The Medawar Prize has been awarded at each of our Society's biennial Congresses since 1990.

The award recognizes the outstanding investigators whose contributions have had such a profound influence on the field of organ transplantation. The Medawar Prize is universally considered to be commensurate with the most outstanding world prizes for scientific achievement.

Application Extended Deadline

May 1, 2022

Eligibility to Award

All full members in good standing will be eligible to be nominated for this award.

Frequency of Award

The Award will be given at each of the TTS Biennial congresses.

Selection of the Recipient

The selection committee consists of the previous five Past Presidents of The Transplantation Society.

Monetary Award

The monetary award will be $25,000.

Past Medawar Laureates

2020
2018
2016
2014
2012
2010
2008
2006
2004
2002
2000
1998
1996
1994
1992
1990
Starzl Prize

CALL FOR NOMINATIONS

Application Deadline

May 1, 2022

Supported by

Early in his career, Dr. Starzl recognized the importance of deceased donation. He pioneered many facets of transplantation, including immunosuppressive drug development, organ preservation, tissue matching, surgical transplant technology, and developed the team approach to organ transplantation; thus paving the way for the success and acceptance of heart, lung, pancreas, intestinal, liver, and kidney transplantation. The international impact of the fruits of seven decades of commitment to transplantation is shown by estimates of over 600 000 Americans and millions of patients around the world that have received a life-saving organ transplantation. He was also credited as having trained over 1,000 medical and surgical transplant specialists over his 50 years in clinical medicine, many of whom have gone on to successfully develop their own transplant

Eligibility to Award

All full members in good standing will be eligible to be nominated for this award.

Frequency of Award

The Award will be given at each of the TTS Biennial congresses.

Selection of the Recipient

The Chair of the Selection Committee will be the then current TTS President, who will choose a selection committee of 3 among the Council members.

Monetary Award

The monetary award will be $10,000.

Previous Winners

2020

Recognition Awards

Call for nominations

These awards recognize individuals who have made a major international impact in the field of transplantation. The awards are given out at each International Congress of The Transplantation Society and carry a monetary award of USD $2,000 each.

Available Awards for 2022

Outstanding Achievement Transplantation Science (Basic)

Outstanding Achievement in Transplantation Science (Clinical)

Outstanding Achievement in Transplantation Science (Developing Country)

Mentorship or Education and Training in Transplantation


Select a year to view past recipient details

2020
2018
2016
2014
2012
2010
2008
2006
WIT Awards

WIT Awards

The Women in Transplantation Steering Committee have created the Woman Leader in Transplantation Award to recognize a woman who has helped further the field of transplantation through research, policies, leadership, initiatives or other regarded contributions. The Unsung Hero Award will be presented to one woman who has had an extraordinary impact in transplantation through community service, volunteering, mentorship or other community based activity. Both Awards are presented during the presidential address at the TTS International Congress.

ELIGIBILITY REQUIREMENTS:
NOMINATION PACKAGE MUST INCLUDE:
AWARD DETAILS
INTERNATIONAL TRANSPLANTATION SCIENCE MENTEE-MENTOR AWARDS

THE TRANSPLANTATION SOCIETY (TTS), ALONG WITH COLLABORATION OF NATIONAL AND INTERNATIONAL SOCIETIES, ACKNOWLEDGES THE CONTRIBUTION OF BASIC SCIENCE TO THE FIELD OF TRANSPLANTATION.

THE INTERNATIONAL TRANSPLANTATION SCIENCE MENTEE-MENTOR AWARDS FOR THE 29TH INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY (TTS 2022) – BUENOS AIRES, ARGENTINA, SEPTEMBER 10-14, 2022.

The Transplantation Society celebrates the contributions of basic science to the field of transplantation with the International Transplantation Science Mentee-Mentor Awards to recognize the efforts of scientists who have advanced our understanding of transplantation science and fostered the development of the young investigators who will be the future leaders in our field.

The application will open in January 2022. Deadline for submission is April 10, 2022.

Click here for more details

ISN-TTS Sister Transplant Centers Program

The ISN and The Transplantation Society (TTS) are pleased to announce the results of the latest round of applications to the ISN-TTS Sister Transplant Centers Program.

Six centers will work in pairs over the next few years toward creating new kidney transplant centers and developing existing kidney transplant programs in the emerging health centers:
• Mittaphab Hospital, Laos
• Ramathibodi Excellent Center for Organ Transplantation, Thailand
• Universiti Teknologi MARA, Malaysia
• Singapore General Hospital-Health Sciences Authority, Singapore
• Hôpital Universitaire de Mirebalais, Haiti
• Beth Israel Deaconess Medical Center, USA

Thanks to generous and dedicated support from the Bambino Gesu Children’s Hospital in Italy, the St. John’s Medical College and Hospital in India has now graduated from the program after completing a fulfilling six-year journey.

St. John’s Medical College and Hospital is now considered to be a center of knowledge, able to support local institutions to advance kidney transplantation in South Asia.

TTS and ISN warmly congratulate these centers on all they have accomplished.

Supporting and emerging health centers benefit from such partnerships:
  • Supporting centers contribute to global health, bringing ethical and competent transplantation to regions of the world with limited or no transplantation;
  • emerging centers connect with a multidisciplinary team of international experts in transplantation.

IPTA 2022 Virtual - Accessible to Everyone!


Hot Off the Press COVID-19 Articles

«HOT OFF THE PRESS» 
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Dr. Enver Akalin.

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

Victoria Hall et al.
N Engl J Med 2022 Feb 16. doi: 10.1056/NEJMoa2118691. PMID: 35172051

This study investigated the duration and effectiveness of immunity in a prospective cohort of asymptomatic 35,768 health care workers in the United Kingdom who underwent routine polymerase-chain-reaction (PCR) testing. 97% of the participants had received two doses of vaccination and 27% had a previous SARS-CoV-2 infection. A total of 2747 primary infections and 210 reinfections were observed. Two doses of BNT162b2 vaccine were associated with high short-term protection against SARS-CoV-2 infection; this protection waned considerably after 6 months. Infection-acquired immunity waned after 1 year in unvaccinated participants but remained consistently higher than 90% in those who were subsequently vaccinated, even in persons infected more than 18 months previously.

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group
Lancet. 2022 Feb 12;399(10325):665-676. doi: 10.1016/S0140-6736(22)00163-5. PMID: 35151397

Between Sept 18, 2020, and May 22, 2021, 9785 patients enrolled in RECOVERY were eligible for casirivimab and imdevimab, of which 4839 were randomly assigned to casirivimab and imdevimab plus usual care and 4946 to usual care alone. 812 (8%) patients were known to have received at least one dose of a SARS-CoV-2 vaccine. In the primary efficacy population of seronegative patients, 396 (24%) of 1633 patients allocated to casirivimab and imdevimab versus 452 (30%) of 1520 patients allocated to usual care died within 28 days (rate ratio [RR] 0·79, 95% CI 0·69–0·91; p=0·0009). The proportional effect of casirivimab and imdevimab on mortality differed significantly between seropositive and seronegative patients (p value for heterogeneity=0·002).

A fourth SARS-CoV-2 mRNA vaccine in strictly seronegative kidney transplant recipients.

Masset C et al.
Kidney Int. 2022 Feb 12:S0085-2538(22)00093-X. doi: 10.1016/j.kint.2022.01.017. PMID: 35167873

This study evaluated 49 nonresponder kidney transplant recipients with a serologic assessment following a fourth mRNA vaccine. The mean age was 63 years, and 47% were men. None of them had a history of COVID-19 infection nor anti-nucleocapsid IgG. Maintenance therapy consisted of calcineurin inhibitors in 77%, antiproliferative drugs in 83%, and steroids in 57%. A total of 21 of 49 patients (42.8%) seroconverted (i.e., positive serology considered by laboratory thresholds) following the fourth injection, with a mean BAU titer of 82/ml. Of note, 4 of them had a high BAU titer (>264/ml), which can be considered as neutralizing. SARS-CoV-2 infection occurred in 1 patient, who previously developed a low humoral response following 4 injections (BAU, 14.2/ml), presenting with mild symptoms and not requiring oxygen supportive care.


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