Welcome to the March issue of Transplantation Direct, which offers a wide range of articles for the whole transplantation community. For those involved in kidney transplantation, we publish a study comparing different frailty score metrics in recipients, and another study questions whether terminal or peak creatinine measurements are more predictive of graft quality in donors with diabetes mellitus. In liver transplantation, we offer results from a prospective pilot study determining whether hemoxygenase-1 is a useful new biomarker to assess early post-transplant allograft function. There are also liver studies using national and international transplant databases to determine if donor age modifies the association between donor sex and mortality, and to assess the impact of donor - recipient age mismatches on liver transplant outcomes. We have two articles related to lung transplantation: one on using a pig model to test a novel whole-body cooling approach to reduce warm ischemia times in the situation of uncontrolled donor lung procurement, and another article focuses on using the lower limit of normal spirometry method to define baseline lung allograft dysfunction after transplantation. In pediatric organ transplantation, investigators report on the use of a medication level variable index to identify patients most at risk for immunosuppression adherence problems. For our readers interested in infectious disease control, we publish an experimental study showing that CMV-specific CD154-expressing T cells are present in a high proportion of seronegative recipients, suggesting these cells could be useful for antiviral prophylaxis. Related to organ donation, this journal issue also contains an article derived from OPTN data that challenges the dogma that a short donor time-to-death is critical in circulatory death transplantation. Finally, as recognition of patient involvement in transplantation policies increases, a study explores use of the social media platform Reddit by various people in the transplantation community. For complete and freely accessible information on all these articles, and more, please visit our Transplantation Direct website.