TRANSPLANTATION Direct - January 2019 Issue

This month in Transplantation Direct offers articles on a variety of important topics. The Transplantation Society of Australia and New Zealand, and other Australian authorities, commissioned a literature review on infectious disease transmission related to organ donation; the results from that review are presented here. We have articles related to kidney transplantation covering topics including "improvable" kidney discard rates during the annual American Transplant Congress meeting; an analysis of survival advantage when faced with transplanting hard-to-place (extended cold ischemia time) kidneys in patients with long dialysis times; the influence and implementation of nonimmunological donor-recipient pairing factors on outcomes, effects, and costs of early vs late conversion from immediate-to-prolonged–release tacrolimus; the immunomics of acute allograft rejection related to immunosuppression choice; and testing of grazoprevir/elbasvir therapy to treat hepatitis C infection in patients with impaired allograft function. In liver transplantation, contributors present data on whether long-term immune responsiveness is retained against ABO antigens. We also have an interesting study examining simultaneous vs sequential heart-liver transplantation. A final note from the editors and editorial staff at Transplantation Direct – we appreciate your continued patronage, and we wish you great success in 2019.

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FREE Online Course for TTS MEMBERS AND the MEMBERS OF THEIR TEAMS
Early Registration is NOW OPEN - IT Just Takes ONE MINUTE TO REGISTER!

Following up on the great success of the Course in Spanish and Portuguese, we have decided to expanded the course to english AND made it available for free to participate in for TTS Members and those in their transplant teams.

Over an eight week period, featuring 20+ online presentations, we will guide you through all the important aspects in immunology.

The course was designed to allow participants to learn at their own pace and time during each week of the course. You can post questions and tutors will respond to them.

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TRANSPLANTATION - WEEK'S MOST DOWNLOADED PAPER

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TRANSPLANTATION - HIGHLIGHTED ARTICLE

Dr Joel Thomas Adler, Editorial Fellow, Transplantation

Socioeconomic Status and Kidney Transplant Outcomes in a Universal Healthcare System: A Population-based Cohort Study.

Naylor KL, Knoll GA, Shariff SZ, McArthur E, Garg AX, Van Walraven C, Austin PC, McCallum MK, Quinn RR, Tan VS, Kim JS.
2018 Sep 21. doi: 10.1097/TP.0000000000002383

The relationship between socioeconomic status (SES) and kidney transplant outcomes has been difficult to understand. Using administrative data from a universal healthcare system in Ontario, Canada, Naylor and co-authors investigated the relationship between SES (measured by the median neighborhood income) and kidney transplant outcomes. SES did not appear to be related to graft outcomes, but higher SES was associated with lower rates of death with a functioning graft, all-cause mortality, and all-cause hospitalization.

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TTS-IRTA Webinar - Updates in pediatric intestinal failure and transplant: Educational strategies and neurodevelopmental assessment
Tuesday, January 22, 2019 - 11:00AM EST

Speaker:		Mary Gallotto, RN BSN, CPN Staff Nurse, Home Parenteral Nutrition Program Boston Children’s Hospital Boston, MA, USA
Speaker:		Colleen Nespor, BSN, MSN,  Clinical Nurse Specialist- Intestinal Rehabilitation/Nutrition Support Team Lucile Packard Children Hospital at Stanford Palo Alto, CA, USA
Speaker:		Stephanie So, MSc. PT, Physiotherapist The Hospital for Sick Children, Toronto Transplant and Regenerative Medicine Centre Group for Improvement of Intestinal Function and Treatment (GIFT) University of Toronto Toronto, ON, Canada
Moderator:		Beverly Kosmach-Park, DNP, RN, FAAN Clinical Nurse Specialist Department of Transplant Surgery Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA

CLICK HERE TO SIGNUP

Webinar Summary:

This webinar will focus on aspects of patient care outcomes within intestinal rehabilitation and transplant.  The topics presented will provide an overview of successful educational interventions for caregivers who are learning central line care and home TPN administration.  Additionally, the webinar will include an overview of neurodevelopmental outcomes in this patient population.  This webinar is being presented by the Allied Health Committee of IRTA. 

Leadership Series Videos Now Available

TTS Transplantation Leadership Series webinars were designed to encompass necessary topics to assure success within key business practices used by medical professionals. The Series was part of a 6-month Leadership program completed in the Spring of 2018. Due to the valuable content of these webinars, TTS has decided to share them with TTS members (Requires TTS Member Login).

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	Mark Briesacher Leading the Future of Healthcare: How mission-led organization succeed through pivotal trends and constant change
	Caryn Corenblum Brain Savvy Leadership Organizational Skills
	Susan Lieff Academic Leadership Paradigms and Practices
	Elizabeth Rider Leadership Strategies, enhancing communication, relationship and values
	Dorry Segev Data Driven Decision Making for Leaders
	James Stoller Leadership, Collaboration and Change in Healthcare
	Teri Turner Leading Innovations

ELPAT LATE ABSTRACT SUBMISISON Deadline
January 14, 2019

ELPAT is a European platform that brings continuity and progress in European research and dialogue on ‘Ethical, Legal and Psychosocial Aspects of organ Transplantation’. The theme of this ELPAT congress is Developing dialogue – Pioneering Practice. We aim to (1) create a multidisciplinary scientific forum for in-depth discussion of issues that are currently challenging the field and (2) through this dialogue to pioneer practices that contribute to improvement in outcomes in transplantation.

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In the News

A medical rarity: Two patients get back-to-back, triple-organ transplants

Source (AP) - Pictured left to right - John J. Fung, Nir Uriel

January 4  - Two 29-year-old transplant patients who underwent the same rare surgeries at University of Chicago Medicine made history after receiving triple-organ transplants to replace their hearts, livers and kidneys–which were all failing.

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First woman pregnant after robot-assisted uterine transplantation

January 9 - The well-known research on uterine transplantation in Gothenburg is now supported by robotic surgery. This change has made operating on the donors considerably less invasive. After the technical modification, a first woman is now pregnant.

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Poor state of kidney care in South Asia for those without means: Study

January 9 - People mostly the poor suffering from Kidney diseases, are not getting adequate treatment facilities in the South Asian countries including Bangladesh, said an international study.

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Biomedical Research Highlighted in Science's 2018 Breakthroughs

January 2 - The journal Science announced its much-anticipated scientific breakthroughs of 2018. In case you missed the announcement, it was another banner year for the biomedical sciences.

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Unethical experiments' painful contributions to today's medicine

January 9 - CNN - Chinese scientist He Jiankui sent shockwaves around the world last year with his claim that he had modified twin babies' DNA before their birth. The modification was made with gene editing tool CRISPR-Cas9, he said, and made the babies resistant to HIV. Scientists from China and around the world spoke out about the experiment, which many say was unethical and not needed to prevent the virus. The scientist had also been warned by peers not to go down this path.

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1st TTS Regional Meeting on Deceased Donation

We are offering low registration fees, which are further reduced for TTS, MESOT, TDTD or TOND Members, nurses and non physicians. Students may attend the meeting for free.

VISIT HTTP://TTSREGIONAL2019.ORG FOR FULL DETAILS

IPTA 2019 - May 4-7, 2019 - Vancouver, Canada

VISIT HTTP://IPTA2019.ORG FOR FULL DETAILS

TRANSPLANTATION - January 2019 Issue

This issue is all about NASH and non-alcoholic fatty liver disease. Perfectly placed to allow postprandial contemplation after the holiday period, this issue contains 19 papers on the subject including the ILTS guidelines for management and many papers on basic pathophysiology through to both registry and large single center reports of short, medium and long term outcomes. Vital reading for those managing liver disease and liver transplantation and also great information for those managing fatty liver disease in other transplant cohorts. A must read issue to start the year with!

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FREE Online Course for TTS MEMBERS AND the MEMBERS OF THEIR TEAMS
Early Registration is NOW OPEN - IT Just Takes ONE MINUTE TO REGISTER!

Following up on the great success of the Course in Spanish and Portuguese, we have decided to expanded the course to english AND made it available for free to participate in for TTS Members and those in their transplant teams.

Over an eight week period, featuring 20+ online presentations, we will guide you through all the important aspects in immunology.

The course was designed to allow participants to learn at their own pace and time during each week of the course. You can post questions and tutors will respond to them.

CLICK HERE FOR EARLY REGISTRATION

TRANSPLANTATION - HIGHLIGHTED ARTICLE

Dr Joel Thomas Adler, Editorial Fellow, Transplantation

The Use of Donation After Cardiac Death Organs for Simultaneous Liver-Kidney Transplant: To DCD or Not to DCD?.

Vinson AJ, Gala-Lopez BL, Tennankore KK, Kiberd BA.
Transplantation. 2018;doi: 1097/TP.0000000000002434.

Donation after circulatory death (DCD) organs are a means to facilitate earlier transplant and reduce deaths on the waitlist. Vinson et al. used Markov modeling to assess the benefit of DCD simultaneous liver-kidney transplant at different MELD scores. The simulations found that waiting for a neurological death donor is the preferred strategy if MELD is less than or equal to 30, but the actual incremental benefit is small. While there are assumptions made in the modeling, this manuscript provides one framework for decision analysis in high risk candidates liver transplantation.

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In the News

Lab grown lungs are transplanted in pigs today, they may help humans tomorrow

Bio-engineered lung prepared for transplant. Air is pumped into the lung to slowly push the culture fluid out of the tissues. This simulates what happens to our lungs during the birth process. (Joan Nichols)

December 28  - There are two major components to building an organ: the structure and the right cells on that structure. A team led by Dr. Joan Nichols, a Professor of Internal Medicine, Microbiology and Immunology at the University of Texas Medical Branch in Galveston, were able to tackle both parts of the problem

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Thousands of Women Are Born Without a Uterus. A New Procedure Offers Them Hope

January 3 - TIME magazine published an article on Uterus Transplantation from the perspective of those afflicted.

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Experimental treatment for type 1 diabetes avoids pancreas transplant - (IPITA Member Mike Rickels Featured)

January 2 - "It takes enormous courage to participate in experimental therapy and then a second dose of courage to become pregnant," said Rickels. "It was one of the most rewarding outcomes we've seen from this program."

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US Study: the kidney shortage kills more than 40,000 people a year

January 2 - As a kidney donor, I talk a lot about the deadly scale of the kidney shortage in the US. A new paper helpfully puts a number on the problem: 43,000. That's the conclusion of researchers Frank McCormick, Philip Held, and Glenn Chertow, in an editorial published in the Journal of the American Society of Nephrologists.

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Woman Develops Donor's Peanut Allergy After Lung Transplant

December 31 - The 68-year-old woman, who had never had a peanut allergy, had a severe allergic reaction to the sandwich, according to a recent report of her case. But someone else did have a peanut allergy, it turned out: the donor who supplied the woman with a transplant lung.

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INDIA (Opinion ARTICLE) - Should public money be sought for expensive organ transplantation procedures?

December 20 - Early liver transplant (LT) for alcohol-associated disease (i.e. without a specific sobriety period) is controversial, but increasingly used. Using the multicenter American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH) cohort, we aimed to develop a predictive tool to identify patients pre-transplant with low-risk for sustained alcohol use post-transplant to inform selection of candidates for early LT candidates.

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TRANSPLANTATION - WEEK'S MOST DOWNLOADED PAPER

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