INFECTIOUS DISEASE COMMITTEE

Current Ongoing Initiatives

• Influenza update :-

  Updates on epidemiology, vaccine recommendations, and available therapies in preparation for the upcoming influenza season

• Management of the solid organ transplantation recipient with diarrhea :-

  Multidisciplinary team (transplant nephrologist, gastroenterologist, and infectious disease physicians) reviewing the available data and providing a consensus algorithm for the management of these patients. Manuscript is being finalized

• Survey of current practices regarding live virus vaccination after solid organ transplantation :-

  Given the emerging data of safety and immunogenicity of live viral vaccination in certain renal and liver recipients, a survey has been created and distributed evaluating current practices and possible barriers to vaccination

• Infection prevention strategies in transplant candidates and recipients with asplenia :-

  Case-based scenarios reviewing the evidence behind prophylaxis recommendations are being created

• Contemporary approaches to toxoplasmosis prevention :-

  Survey instrument to capture current, international practices regarding the prevention of toxoplasmosis after pediatric SOT is underway

• Antimicrobial prophylaxis in liver transplant recipients :-

  Working on creation of a case-based survey tool to summarize the current state of clinical care regarding antibiotic and antifungal prophylaxis strategies among pediatric liver transplant recipients

• Review of emerging therapies for multi-drug resistant bacterial infections

Recently Completed Initiatives

• Approach to the transplant candidate with active infection :-

  Expert opinion providing a framework for decisions regarding acceptance or delaying solid organ transplantation in candidates with active infections:
  https://www.ncbi.nlm.nih.gov/pubmed/30838753

• CMV guidelines and pediatric case-based commentary :-

  ID CARE members who participated in the 3rd CMV consensus conference and guidelines formulated a case-based manuscript highlighting key points and changes, with an emphasis on pediatric-specific topics:
  https://onlinelibrary.wiley.com/doi/full/10.1111/petr.13276

• Pneumocystis prophylaxis strategies across centers :-

  A survey-based assessment tool was created for evaluation of current Pneumocystis jirovecii prophylaxis strategies in various centers, with data submitted for consideration of publication in Pediatric Transplantation

• Live virus vaccination after solid organ transplantation :-

  ID CARE members who participated in a 2-day consortium of vaccine experts provide a review of the growing evidence regarding the efficacy and safety of live-attenuated viral vaccines in selected patients after solid organ transplantation and expert recommendations:
  https://onlinelibrary.wiley.com/doi/full/10.1111/petr.13571

• Emerging mosquito-borne viruses and impact on transplantation :-

  As a request form the IPTA council, a manuscript was created by experts in the field addressing the topic, focusing on Zika, dengue, and chinkungunya and relevance to pediatric SOT and HCT recipients:
  https://www.ncbi.nlm.nih.gov/pubmed/30338634

• EBV/PTLD consensus conference

Members of the Infectious Disease Committee